12/case directions: apply generously to tooth brush & brush as normal or as directed by a dentist or doctor. For human use only. Xylitol is not good for dogs. Ingredients: 22ppm silversol solution (deionized water, purified silver), xylitol, tea, carbomer, peppermint oil. No triclosan, glycerin, fluoride, parabens or sls. Non-abrasive/no bpa 06/21/19