24/case directions: insert nozzle into nostril & depress pump completely while breathing in through the nose. Spray 1-2 times in each nostril up to 3 times per day. Clean nozzle after each use. Ingredients: purified water, medical grade manuka honey, glycerin, saline, and as a preservative, natural fruit & plant extracts containing citric acid & ascorbic acid. 03/15/17